Biological Foundations of PRP in Orthopedic Regeneration

Orthopedic injuries involve complex damage to tendons, ligaments, cartilage, and bone microstructures. Platelet-rich plasma therapy addresses these challenges by delivering a high concentration of autologous growth factors that initiate tissue regeneration at the cellular level.

PRP releases platelet-derived growth factor, insulin-like growth factor, and vascular endothelial growth factor, which collectively enhance angiogenesis, stimulate collagen synthesis, and promote extracellular matrix repair. These biological mechanisms make PRP particularly effective for musculoskeletal regeneration.

For orthopedic reproducibility and safety, PRP preparation must meet medical device standards. CE Marked Class IIb systems achieving platelet counts above 4 million ensure consistent biological activity suitable for clinical protocols and academic training.

PRP in orthopedics represents a paradigm shift from symptom control to biologically driven tissue restoration.